SIEMENS TAC_900.072 Smart Manufacturing for Pharmaceuticals User Guide

SIEMENS TAC_900.072 Smart Manufacturing for Pharmaceuticals

Specifications

• Product: Digital Industries Smart Manufacturing System for Pharmaceuticals
• Operational Focus: Maximize operational readiness and efficiency without compromising quality
• Key Features: Automation systems, digital twin integration, operational data insights

Product Usage Instructions

Accelerate Process and Plant Engineering

Collaborate on designing primary and secondary manufacturing processes, ensuring smooth coordination across engineering teams.
Utilize a comprehensive production digital twin to scale up, validate, and optimize processes efficiently.

Key Steps:

1. Collaboratively design manufacturing processes
2. Implement a production digital twin for process optimization
3. Manage plant and equipment lifecycle effectively

Enhance Operational Agility and Efficiency

Implement flexible and paperless manufacturing practices to ensure operational agility and efficiency.

Key Steps:

1. Adopt flexible manufacturing practices
2. Transition to paperless operations

Fully Integrated Operations Approach

Integrate engineering, production, and performance aspects to achieve speed, scale, complexity management, and quality in operations.

Key Aspects

• Agile process and plant engineering
• Intelligent, lean, and sustainable operations
• Operational readiness and efficiency enhancement

FAQ

Q: What are the urgent challenges faced by the pharmaceutical industry?

A: Challenges include patient-centric healthcare, diverse product portfolios, technology advancements, cost pressures, and regulatory compliance.

Q: How can pharmaceutical companies keep up with demand?

A: By addressing cybersecurity threats, enhancing production scalability, diversifying drug portfolios, ensuring regulatory compliance, and leveraging digital transformation.

Q: Why is digital transformation crucial for pharmaceutical manufacturing?

A: Digital transformation enables improved operational efficiency, agility, and quality maintenance in pharmaceutical manufacturing processes.

Smart manufacturing for pharmaceuticals

• Maximize operational readiness and efficiency without compromising quality

Urgent challenges the pharma industry

What are the urgent challenges the pharma industry is facing?

• Patients: growing and aging population, patient-centric healthcare, patient data.
• Pace of change: technology development, supply chain complexity, uncertainty in success.
• Products: diverse product portfolios, new manufacturing techniques, drug affordability.
• Performance: cost pressure, glocalization, outsourcing, energy/resource efficiency.

Traditional manufacturing processes are not able to meet varying global, local and patient needs quickly

Digital transformation is key

There is still room for significant improvement when it comes to leveraging digital and automation technologies.

• 70% of businesses will attempt to transform themselves digitally within the next decade
• 30% will succeed

How can you increase your chances of success in a rapidly evolving pharma landscape?

• Choose a partner who has deep knowledge of the pharmaceutical industry and who understands the manufacturing challenges and related technologies.

Why you should take a new approach to pharma manufacturing

• 55% of drug shortages in 2021 were attributed to production delays and quality-related issues
  • Source: PharmTech
• $15m is the average cost of launch delay per drug, per day
  • Source: BusinessWire
• 10-20% of baseline cost reduction with a smart manufacturing strategy
  • Source: McKinsey

How to maximize operational readiness and efficiency without compromising quality

It’s imperative to adopt an end-to-end approach to operations by integrating automation systems with a digital twin of the entire pharmaceutical manufacturing process, production lines and equipment. This enhances the flexibility of your plants and helps you produce faster and at scale while maintaining quality. The insights from operational data will help increase agility, build a proactive, long-term manufacturing strategy and continuously improve operations from development to performance.

Accelerate your process

Accelerate your process and plant engineering with a collaborative approach

• Collaborative design of primary and secondary manufacturing processes Streamline collaboration across engineering teams
• Plant and equipment lifecycle management Ensure data integrity across the plant lifecycle
• Comprehensive production digital twin Scale up, validate and optimize processes using a digital copy of your plant
• Modular production setup Minimize start-up time by seamlessly plugging in pre-validated equipment

Ensure operational agility and efficiency with flexible and paperless manufacturing

• Automated and flexible manufacturing execution Facilitate automated and manual data recording for review by exception
• Integrated shop floor production systems Harmonize data and achieve end-to-end visibility of your entire production process
• Personalized manufacturing Apply the latest digital and automation technologies to individualized production
• Continuous manufacturing Enables continuous processing and real-time product release
• Training and maintenance with VR/AR Ensure safety and efficiency using immersive operator training

Production Targets

Meet production targets and continuously optimize with intelligent, lean and sustainable operations

• Production availability and reliability Gain insight into performance, quality and sustainability to initiate corrective actions, when necessary
• Production performance and quality assurance Improve efficiency and ensure quality by enabling transparency

Pharma Companies

Pharma companies that apply Siemens’s smart manufacturing approach can expect to achieve

• 5 months to repurpose a vaccine plant
• 2.5 months to replace paper with an MES
• 20% reduction in operating costs with continuous manufacturing
• x2 yearly production capacity
• 40% more energy-efficient plant

5 results

Siemens Smart Manufacturing Solution for Pharmaceuticals helps you achieve

1. Accelerate process and plant engineering to reduce time-to-market and maximize revenues
2. Boost productivity by moving from a classic batch process to continuous manufacturing
3. Increase flexibility and agility to produce diverse product portfolios at various scales
4. Ensure right-first-time manufacturing within required specifications
5. Meet production and sustainability targets to drive continuous improvement

What’s next?

• Discover how the Siemens Smart Manufacturing Solution for Pharmaceuticals can help you manufacture life-saving products faster and at scale.

• © 2024 Siemens. A list of relevant Siemens trademarks can be found here.

• Other trademarks belong to their respective owners.

For more information, visit siemens.com/pharma.

References

• Pharmaceutical Industry - Siemens Xcelerator Marketplace Global

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