COBIOER BIOSCIENCES U2OS Human Cell Surface Receptor Instructions

June 9, 2024
COBIOER BIOSCIENCES

COBIOER BIOSCIENCES U2OS Human Cell Surface Receptor Instructions

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HVEM/U2OS Cell
CBP74178

Background

HVEM (CD270, TNFRSF14) is a human cell surface receptor intheTNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Bindingof HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα(lymphotoxin-α), causes a co-stimulatory signal which can activatelymphoid cells. Interaction with BTLA (CD272) or CD160 causesaco-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2andTRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

Introduction

Expressed gene: HVEM
Stability: 32 passages (in-house test, that not means the cell line will beinstable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: Mccoy’s5A+10%FBS+2ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay

Representative Data

Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2 Reporter Cells (C11) B Samples With HVEMU2OS Cells (C7)

Figure 1. Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2

Reporter Cells (C11) By Samples With HVEM/U2OS Cells (C7).

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