Honeywell Sensors and Switches in Medical Chemistry and Immunoassay Analyzers User Guide

Sensors and Switches in Medical
Chemistry and Immunoassay
Analyzers
An Application Note

Background

Clinical laboratories conduct many complex and diverse tests in order to diagnose illnesses. Chemical and immunoassay analyzers (which can be combined into one piece of equipment) are used to determine the presence or concentration of a substance in blood, urine, or serum. They are used to test glucose, cholesterol, hormones, drugs, infectious diseases, cardiac markers, tumor markers, etc., which helps diagnose and treat many diseases or other conditions such as cancer, diabetes, fertility, hepatitis, kidney conditions, and thyroid, to name a few.
Various test methodologies may be available on a machine, including immunoassay, potentiometric, calorimetric, and enzyme-linked immunosorbent assay (ELISA). While differences in test methodologies exist, the overall operation is similar. Smaller-sized analyzers can be placed bench-top or on carts, while larger-sized equipment requires floor space.

Solutions
Honeywell manufactures many products that may be used to measure fluid volume; detect blockages; heat and cool samples/reagents; open and close covers/doors; humidity detection; filling level detection; sample carriage/reagent position detection; and positive patient confirmation and reading the physician’s test orders off the barcode. (See Figure 1.) y Analyzers

Figure 1. Potential Honeywell Products Used in Chemistry Analyzers

1. Sample/Reagent Dispenser
Measurement of fluid volume; detection of air and occlusion in pipetting system
Pressure Sensors – Board Mount
TruStability TM RSC Series, HSC Series, SSC Series, 24PC and 26PC Flow-Through SeriePressure Transducers – Heavy Duty
MLH Series, PX2 Series
2. Incubator
Heating and cooling of samples and reagents

3. Covers/Doors
Open detection
Hall-effect Position Sensor ICs
SS351AT, SS451A
MICRO SWITCH Snap-in Panel Mount Basic Switches
DM Series
MICRO SWITCH Subminiature Basic Switches
ZM Series, ZX Series

4. Leak Detection System
Measurement of high humidity levels to detect leaks
HIH6000, HIH6100, HIH7000 Series Honeywell HumidIcon™ Digital Humidity/Temperature Sensors

5. A reagent or Waste Container
Liquid level and position sensing: filling level detection for magnet and buffer container
Hall-effect Position Sensor ICs
SS351AT, SS451A

6. Sample Identification
Barcode scanning for patient confirmation and, sometimes, verification of the physician’s order
Ultra-Slim Area-Imaging Engine
N6600 Series
Barcode Decoding Software
SwiftDecoder TM

Customer Needs of a Chemical or Immunoassay Analyzer (See Table 1 and

Figure 2.)

Laboratory technicians often require the following of a chemical or immunoassay analyzer:

• Provides accurate, repeatable measurement results
• Provides fast delivery of measurement results
• Reduces or eliminates errors in data interpretation
• Contributes to efficient patient health care
• Reduces unscheduled downtime of equipment
• Provides a low MTBF (Mean Time Between Failure) rate
• Improves labor efficiency and effectiveness

Table 1. Operation of a Chemistry or Immunoassay Analyzer

| Reagent
Loading| Sample
Loading| Liquid
Handling| Mixing/
Separating| Analyzing| Rinsing/
Cleaning
---|---|---|---|---|---|---
Opera
tion| •  Barcoded reagents
are loaded• Reagents/buffer
are kept cool at 4°C[39.2°F] for longevity| •  Test tubes or vials are loaded
• Barcode identification of samples•  Samples are kept at ambient temperature or heated to 37°C[98.6°F]| •  Draw fluid from sample vial and reagent container
•  Transfer to pipette ortest tube|   Magnetic beads,

for breaking and
absorption
Agitation, centrifuge

•  Sample maintained

at 37°C [98.6 °F] or

heated

| •   Sample reagent

mix passes through

photometer

•  Optical or electric

analysis of fluid

| •  Flush between tests

•  System test with water

Sensor/
Switch| •  Switches may be used on covers and doors

•  Liquid level of
reagent/buffer
volume

•  Optical barcode

reader for reagent

identification

| •  Optical sensors detect
position of vials and carriage movement
• Barcode scan
engine or
software
for positive patient
confirmation before
sampling| •  Capacitive liquid
level for detection of immersion of pipette tip
•  Pressure sensor for air  or occlusion detection; liquid media compatible
•  Humidity sensor provides leakage
detection| •  Custom heater

•  Thermistor or

temperature sensor

monitors reagent and sample temperature

| •  LED light source

•  Photodiode

| •  Pressure sensor or
transducer for  flush monitoring•  Liquid level for
waste container

Figure 2. Operation of a Chemistry or Immunoassay Analyzer

APPLICATION NOTE | Sensors and Switches in Medical Chemistry and Immunoassay Analyzers | sps.honeywell.com/ast

Fluid Handling in a Chemistry Analyzer

Typically, in a chemistry analyzer, a pipette draws the sample fluid and deposits it into another vial or container for mixing or analysis. (See Figure 3.) Pressure sensors are used to ensure that the right amount of fluid is being measured while the sample is being drawn. They can also be used to detect obstructions or misplacement of the pipette in the sample vial (see Figure 4), and if the air is being drawn instead of fluid.
These pressure sensors need to provide consistent accuracy, stability, and repeatability at low-pressure levels. However, in the same systems, they also need to withstand higher pressures that are produced when the fluid pathway is flushed or cleaned. All of this is done while in direct contact with the liquid media being measured.

Customer Needs:

• Accurate sample volumes
• Stable and repeatable
• Eliminate carry-over between tests; thorough flushing
• Fast cycle times

Pressure Sensor Function in the Application:

• Capable of detecting if the probe is clogged
• Capable of detecting if the air is being drawn instead of fluid

Pressure Sensor Needs in the Application:

• Wet media compatibility
• Accuracy and repeatability at low pressures
• Ability to withstand higher pressures from flushing or cleaning

For more information about selecting pressure sensors for potential use in chemistry analyzers, view our white paper.

Figure 3. Fluid Handling in a Chemistry Analyzer

A pressure sensor ensures that the correct amount of fluid is being measured while the sample is being drawn.

Figure 4. Pressure Sensor Detecting Obstruction in a Pipette

Some systems will compare the pressure profile of the aspiration to a known “good” or “bad” profile.

Table 2. Capabilities for Diagnostic and Analytical Equipment

A broad portfolio of products is designed to provide enhanced performance, accuracy, and reliabilit

PRESSURE – BOARD MOUNT

| TruStability™ RSC Series,
HSC Series, SSC Series| Enhanced stability and accuracy;
configurable; liquid media options; digital output; stable; accurate at low pressure; contamination and corrosion-resistant; small size high resolution (RSC Series)| It May be used for flush monitoring during
the rinsing/cleaning process, and for air
or occlusion detection during the liquid
handling process.
---|---|---|---
| 24PC Series,
26PC Series| Wet/wet capability; a variety of port configurations provide flexibility making
pneumatic connections; miniature package;
flow-through configurations; analog output|

PRESSURE – HEAVY DUTY

| MLH Series| Fully media-isolated for harsh chemicals;
pressures up to 8,000 psi; multiple
configurations simplify design; all metal wetted parts allow for potential use in a variety of fluid applications;  rated IP65 or better for protection from most harsh environments| It May be used as an alternative to board
mount pressure sensors for flush
monitoring during the rinsing/cleaning
process.
---|---|---|---
| PX2 Series| Liquid compatible; pressures up to 1000 psi;
compatibility with a variety of harsh media,
up to IP69K ingress protection and 100 V/m
radiated immunity allow for use in tough
environments

POSITION DETECTION

| DM Series MICRO
SWITCH Snap-in Panel
Mount Basic Switches| Compact, lightweight design; accurate;
repeatable and consistent performance up to
one million lifecycles| It May be used for position detection of
covers and doors during the reagent
loading process.
---|---|---|---
| ZM Series, ZX Series
MICROSWITCH
Subminiature Basic
Switches| Subminiature package size; integral stainless
steel levers; a variety of electrical terminations
| SS351AT, SS451A
Hall-effect Position
Sensor ICs| Omnipolar; sensitive; flexible use; low voltage
3 Vdc capability; built-in reverse polarity
protection; non-contact; long-term reliability,
small size; easy to install

THERMAL MANAGEMENT

| 192 Series, 194 Series
Thermistors| Resistance temperature curve;
interchangeability; accurate; enhanced stability; enhanced life; cost- effective; small;
can be integrated into the heater assembly| It May be used to monitoring reagent and sample temperature at 37°C [98.6°F] during the sample loading process and the mixing/separation process to provide consistent test results.
---|---|---|---
| Heater Assemblies| Custom flexible heater assemblies with thermal modeling capabilities for optimizing designs in unique applications; thermal modeling; one-stop-shop for assembly| It May be used to monitoring reagent and sample temperature at 37°C [98.6°F] during the mixing/separation process to provide consistent test results.
| HIH6000 Series,
HIH6100 Series,
HIH7000 Series
HumidIcon Digital
Humidity/Temperature
Sensors| Combined humidity and temperature sensor;
industry-leading long term stability (1.2 %RH over five years); enhanced reliability; enhanced relative humidity; more energy-efficient; ultra-small package| May be used for leakage detection during
the liquid handling process.

BARCODE SCANNING

| CM Series Compact 2D Imager Module for Kiosk Data Capture
Operations| Self-contained, easy-to-mount 1D and 2D
barcode scanning solution, whether decoding
mobile phone screens or paper; selection of optics allow you to meet the performance
requirements of your application| It May be used for positive patient
confirmation and sometimes verification
of the physician’s order prior to the
reagent loading process and the sample
loading process.
---|---|---|---
| N6600 Series UltraSlim
Area-ImagingEngine| High-performance barcode imaging; slim
and compact; integrates Honeywell Adaptus
6.0 technology for unparalleled 1D and 2D
scanning performance
| SwiftDecoder™ Barcode
Decoding and Character
Recognition Software| Accurate industrial-grade decoding and
character recognition; proven in millions
of barcode scanners and OEM products
worldwide

Warranty/Remedy
Honeywell warrants goods of its manufacture as being free of defective materials and faulty workmanship during the applicable warranty period. Honeywell’s standard product warranty applies unless agreed to otherwise by Honeywell in writing; please refer to your order acknowledgment or consult your local sales office for specific warranty details. If warranted goods are returned to  Honeywell during the period of coverage, Honeywell will repair or replace, at its option, without charge those items that  Honeywell, in its sole discretion, finds defective. The foregoing is the buyer’s sole remedy and is in lieu of all other warranties,  expressed or implied, including those of merchantability and fitness for a particular purpose. In no event shall Honeywell be liable for consequential, special, or indirect damages.

While Honeywell may provide application assistance personally, through our literature and the Honeywell website, it is the buyer’s sole responsibility to determine the suitability of the product in the application.
Specifications may change without notice. The information we supply is believed to be accurate and reliable as of this writing. However, Honeywell assumes no responsibility for its use. 
For more information
To learn more about Honeywell Advanced Sensing Technologies,
call 1.800.537.6945, visit our website, or e-mail inquiries to info.sc@honeywell.com
To learn more about Honeywell’s scan engines and barcode software, visit our website.

Honeywell Advanced Sensing Technologies
830 East Arapaho Road
Richardson, TX 75081
sps.honeywell.com/ast

009042-6-EN | 6 | 04/21
© 2021 Honeywell International Inc.

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