Thermo SCIENTIFIC Vanquish Neo Flex Quaternary Vanquish UHPLC System Instruction Manual
- July 8, 2024
- Thermo Scientific
Table of Contents
Thermo SCIENTIFIC Vanquish Neo Flex Quaternary Vanquish UHPLC System
Product Information
Use this checklist in conjunction with the Pre-Installation Requirements Guide for the Thermo Scientific™ Vanquish™ UHPLC system, to ensure adequate preparation prior to the start of an installation. Complete the checklist and return to your installation contact/coordinator when ready to schedule your installation.
| No. | Item | Check To Acknowledge |
|---|---|---|
| 1 | All laboratory remodeling/building has been completed. | **** |
| 2 | Principal operator will be available during the installation/certification | |
| period. | **** | |
| 3 | Available floor area is sufficient and flooring will support the load. |
4| Sufficient bench space is available for all of the equipment.
List the following:
| ****
| Width:|
Depth:|
Height:|
5
| Workbench can support the load of the LC system [up to 100kg (190 lbs),
(System with 1 column compartment, without Charger)] and is free from
vibration. (System with Charger, add 35kg, each additional Column Compartment
add 15kg)|
6| Lighting is adequate.|
7| Main power is installed and is in compliance with local electrical safety
laws.| ****
8
| Power is free from fluctuations due to slow changes in the average voltage
or changes due to surges, sags, or transients.|
9| Air conditioning is adequate for temperature, humidity, and particulate
matter control. The laboratory can be maintained at a constant temperature,
between 10 and 30 °C (50 and 86 °F).|
10| Relative humidity is between 20% and 80% with no condensation.|
11| The laboratory has adequate ventilation.|
12| System work area is free from magnetic disruption and electrostatic
discharge.| ****
13|
- The following HPLC grade chemicals must be available:
- Water (Fisher Scientific Catalog No. W5-1, or equivalent)
- Methanol (Fisher Scientific Catalog No. A452-1, or equivalent)
- Isopropanol (Fisher Scientific Catalog No. A416-1, or equivalent)
- Formic Acid (for rear seal wash)
Note: LC/MS Grade chemicals are also acceptable, e.g. Fisher Optima.
The installation of a Vanquish Neo System requires the following solvents:
- Water, Optima™ LC−MS grade (Fisher Scientific Catalog No. W6-212 or equivalent)
- Acetonitrile, Optima™ LC−MS (Fisher Scientific Catalog No. A955-212 grade or equivalent)
| ****
|
- Isopropanol, Optima™ LC−MS grade (Fisher Scientific Catalog No. A461−212 grade or equivalent)
- Water with 0.1% Formic Acid, Optima™ LC−MS grade (Fisher Scientific Catalog No. LS118−500 grade or equivalent)
- 80% Acetonitrile with 0.1% Formic Acid, Optima™ LC−MS grade (Fisher Scientific Catalog No. LS122-500 grade or equivalent)
- Formic Acid (FA), Optima™ LC−MS grade (Fisher Scientific Catalog No. A117-10X1AMP grade or equivalent)
Fishersci: 800-766-7000 or www.fishersci.com
|
---|---|---
14| All relevant safety regulations are complied with.| ****
15
| Your laboratory has a waste disposal system for solvents and located below
bench level. Waste reservoir, minimum 2 L.|
16| For systems with a Vanquish Charged Aerosol Detector – A source of dry
nitrogen gas (or compressed air if nitrogen generator purchased) is available
in the laboratory with a 1/4″ O.D outlet. Must meet requirements outlined in
Section 9.1 of the CAD operators manual (70-80psi) and the Pre-installation
Requirements Guide (chapter 4.7)|
| Note the distance between installation location and gas source:| ****
17| Computer system purchased with the instrument:| Yes:| No:|
18| Computers supplied by the customer must meet minimum specifications for
operating the Chromeleon version being used with the Vanquish system. (see
attached requirements)
Note: When running the Vanquish system in combination with a mass spectrometer, the computer controlling the mass spectrometer can be used for running the Vanquish system as well.
| ****
19| For Customer supplied computers, the service engineer will need to have
administrative privileges on the computer during the installation .
Alternatively, a customer representative with these privileges must be present
during installation.
Delays to installation due to lack of IT support may result in a billable charge.
| ****
Provide requested additional information
Are there any local characteristics that could influence the installation?
If YES , please attach details of characteristics.
| ****
Yes
| ****
No
---|---|---
Have any special acceptance specifications been agreed to as a term of sale?
If YES , please attach full details of specifications.
| ****
Yes
| ****
No
Is there any additional equipment that needs to be interfaced to the system?
If YES , please attach full details of additional equipment.
| ****
Yes
| ****
No
Confirm space/weight suitability
Most Vanquish modules are stackable – the column compartment(s) are situated to the side of the stack. Please calculate the total required bench space from the dimensions listed below. These dimensions include the required venting space surrounding the instruments. Please note the total weight, especially if the system will be installed on a lab cart.
WARNING: Risk of tilting system stack A one-stack configuration may exceed the maximum allowed height. If the system configuration is higher, the system stack poses a tilting risk which can entail personal injury. If your configuration is higher, you need to stabilize the stack with one of the following safety measures:
- Use a stack stabilization kit (see table below).
- Build up the system in two separate stacks
The following table shows which stack stabilization kit you need for which stack height. The heights are measured from the table surface to the solvent rack railing. Due to production and installation tolerances, the actual stack height can be up to 2 cm higher than the limit. This tolerance is acceptable.
| Stack height | Stabilization required |
|---|---|
| Up to 100 cm | None Example: Configuration with pump, autosampler, diode |
array detector and charged aerosol detector
Up to 123 cm| One of the following kits:
• Bench clamp kit
• Stack stabilizer kit
• IonBench with stack mounting kit
Up to 139 cm| Bench clamp kit
139 cm and higher| Build up the system in two separate stacks
| Component | Height | Width | Depth | Weight |
|---|---|---|---|---|
| cm | in | cm | in | |
| Solvent Rack Vanquish (without bottles) | 12.1 | 4.0 | 42 | 16.6 |
8.8
System Base| 6| 2.3| 42| 16.6| 42| 16.6| 5| 11.0
Binary Pump H| 19.2| 7.6| 42| 16.6| 62| 24.4| 32| 70.5
Quaternary Pump F/C/CN| 19.2| 7.6| 42| 16.5| 62| 24.4| 17| 37.5
Binary Pump F/C| 19.2| 7.6| 42| 16.5| 62| 24.4| 20| 44.1
Dual Pump F/C/CN| 19.2| 7.6| 42| 16.6| 62| 24.4| 20| 44.1
Isocratic Pump C| 19.2| 7.6| 42| 16.6| 62| 24.4| 17| 37.5
Binary Pump N| 19.2| 7.6| 42| 16.6| 62| 24.4| 26| 57.3
Split Sampler HT/FT| 29| 11.4| 42| 16.6| 62| 24.4| 25| 55.1
Split Sampler CT| 29| 11.4| 42| 16.6| 62| 24.4| 24| 52.9
Split Sampler C| 29| 11.4| 42| 16.6| 62| 24.4| 22| 48.5
Dual Split Sampler HT/FT| 29| 11.4| 42| 16.6| 62| 24.4| 29| 63.9
Split Sampler NT| 29| 11.4| 42| 16.6| 62| 24.4| 26| 57.3
Charger Module| 75| 29.5| 33.9| 13.4| 62| 24.2| 35| 77.2
Column Compartment H/C| 70| 27.6| 11.1| 4.4| 42.2| 16.6| 14| 30.9
---|---|---|---|---|---|---|---|---
Column Compartment N| 15.9| 6.3| 42| 16.6| 62| 24.4| 10.7| 23.6
Variable Wavelength Detector F/C| 16| 6.3| 42| 16.6| 51| 20.1| 16| 35
Diode Array Detector HL| 16| 6.3| 42| 16.6| 51| 20.1| 17.0| 37.5
Diode Array Detector FG/CG| 15.9| 6.3| 42| 16.6| 62| 24.4| 17.0| 37.5
Multi-Wavelength Detector CG| 15.9| 6.3| 42| 16.6| 62| 24.4| 17.0| 37.5
Fluorescence Detector F/C| 15.9| 6.3| 42| 16.6| 51| 20.1| 21| 46.3
Charged Aerosol Detector F/H| 19.2| 7.6| 42| 16.6| 62| 24.4| 17.5| 38.6
Integral Fraction Collector FT| 23| 9.1| 42| 16.5| 62| 24.4| 23| 53.7
Refractive Index Detector C| 16| 6.3| 42| 16.6| 62| 24.4| 17| 36.4
Vanquish Neo System| 82| 32.2| 45| 17.7| 65| 25.6| 66| 145.5
Minimum bench-top space requirements for the installation of a Vanquish UHPLC system with different numbers of VTCCs (Vanquish Column Compartment H) excluding data system and printer):
| LC System | Width | Depth |
|---|---|---|
| cm | inch | |
| Vanquish UHPLC system with 1 VTCC | 64 | 25.2 |
| Vanquish UHPLC system with 1 VTCC and Charger | 108 | 42.5 |
| Vanquish UHPLC system with 2 VTCCs | 86 | 33.9 |
| Vanquish UHPLC system with 3 VTCCs | 108 | 42.5 |
| --- | --- | --- |
| Vanquish UHPLC system with 3 VTCCs and Charger | 152 | 59.8 |
| Vanquish Neo system with 1 VNTCC | 45 | 17.7 |
Pre-installation System Information
Pre-installation system familiarization information:
Please use the following QR code or URL to access Vanquish and UltiMate system familiarization information. This information will provide all necessary familiarization points for new users and should be reviewed prior to your installation. At the time of installation, your service engineer will review this information in person and can answer any questions you may have.
- www.thermofisher.com/myLC
- Provide any additional notes or comments for installation: ……………………………………………………………
- Sign/Date for confirm readiness for installation: ……………………………………………………
- Customer: …………………………………
- Date: …………………………………
Addendum – PC Requirements
PC Hardware Requirements
The table below shows the minimum and the recommended PC configuration for a stand-alone installation of Chromeleon 7.3.2. PCs meeting minimum requirements may be sufficient for some low-demand applications, but will not provide satisfactory performance in many applications. PCs meeting recommended requirements should be suitable for general applications.
The following information is valid for Chromeleon 7.3.2.
| Type | Specification |
|---|---|
| Processor | |
| Minimum |
With 1 DAD-3000RS
With 2 DAD-3000RS
With MS
With Agilent ICF / Waters ICS
With GC-MS Recommended
Recommended with Agilent ICF / Waters ICS (running one or two drivers)
| 3 GHz IntelTM CoreTM 2 Duo
3 GHz Intel Core 2 Duo
3 GHz Intel Core i7
2.4 GHz Dual Core Processor
3 GHz Intel Core 2 Duo
2.4 GHz
3.0 GHz Intel Dual Core i7 or better
3.0 GHz Intel Quad Core i7* or better
RAM|
| Recommended| 16 GB
With 1 DAD-3000RS| 16 GB
With 2 DAD-3000RS| 16 GB
With MS| 16 GB
With Agilent ICF/|
Waters ICS:| 16 GB or greater
Secondary storage|
| Recommended:
With 2 DADs: With MS
| 120 GB HDD or SSD*
1 TB
1 TB
Optical Drive| DVD
Display|
---|---
| Recommended| 1440 x 900 or higher resolution
Chromeleon has been tested with monitors set to 96 DPI at 100% scaling. Other DPI and scaling values may cause UI elements to display incorrectly.
USB Ports|
| license device:| 1 port
Thermo Scientific modules:| 1 or more additional port(s)
Refer to the Chromeleon 7|
Online Help for further|
information with regard to|
*These hard disk requirements are set to enable storage of a substantial amount of data. The software itself requires approximately 8 GB disk space on the C drive (twice as much during an update). In addition, a few GB disk space must always be available on the C drive for sequences cached in the XVault™ . Chromeleon will benefit from the increased speed of solid state drives (SSD). For more information refer to the Chromeleon Installation Guide.
PC Operating System Requirements
Chromeleon 7.3.2 has been validated for stand-alone use on Microsoft Windows 10 Enterprise (64-bit edition), Microsoft Windows 8.1 Pro (64-bit edition) and later is also validated, but use is strongly discouraged.
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