Medtronic 780G System Real World Evidence User Manual

June 1, 2024
Medtronic

Medtronic 780G System Real World Evidence

Medtronic-780G-System-Real-World-Evidence-PRODCUT

Specifications

  • Product Name: MiniMedTM 780G system
  • Indication: For use by patients aged 7-80 years with Type 1 diabetes
  • Real-World Evidence: Clinical outcomes in a wide T1D population

Delivers proven clinical outcomes in a wide T1D population

Scope of the analysis and methods

  • Scope of the analysis
    • Uploaded on CareLink™ Personal from 27 August 2020 to 02 December 2022
    • 61,481 users or caregivers who provided their consent for their data to be aggregated
    • From countries where local data privacy regulation permits data analysis
  • Methodology:
    • 3 cohorts were analyzed for the overall population and per-user self-reported age ≤15 or >15 years*
  • Post-AHCL cohort
    • All users with ≥10 days of SG data after initiating AHCL (N=61,481)
  • Pre- and post-AHCL cohort
    • All users with ≥10 days of SG data before and after initiating AHCL (N=15,395). The analyses are adjusted for baseline TIR (pre-AHCL initiation). This is the cohort used for statistical analysis
  • Longitudinal cohort
    • All users with ≥10 days of SG data in each of the first 12 months after initiating AHCL (N=11,617)

Medtronic-780G-System-Real-World-Evidence-FIG-1

The MiniMed™ 780G insulin pump is indicated for use by patients aged 7-80 years with Type 1 diabetes.
Glucose Management Indicator (GMI) based on reported mean glucose values.

Calculated using JAEB https://www.jaeb.org/gmi/.

  1. Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August 2020 to Dec 2022..
  2. Battelino T, et al. Diabetes Care 2019; 42: 1593-1603.

Achieving glycaemic targets

Medtronic-780G-System-Real-World-Evidence-FIG-2

The MiniMed™ 780G insulin pump is indicated for use by patients aged 7-80 years with Type 1 diabetes.
Glucose Management Indicator (GMI) based on reported mean glucose values.

Calculated using JAEB https://www.jaeb.org/gmi/.

  1. Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August 2020 to Dec 2022..
  2. Battelino T, et al. Diabetes Care 2019; 42: 1593-1603.

Users improved clinical outcomes vs Pre-SmartGuard™ initiation

Medtronic-780G-System-Real-World-Evidence-FIG-3

The MiniMed™ 780G insulin pump is indicated for use by patients aged 7-80 years with Type 1 diabetes.
Glucose Management Indicator (GMI) based on reported mean glucose values.

Calculated using JAEB https://www.jaeb.org/gmi/.
Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August 2020 to Dec 2022.

Between paediatrics and adults

Medtronic-780G-System-Real-World-Evidence-FIG-4

The MiniMed™ 780G insulin pump is indicated for use by patients aged 7-80 years with Type 1 diabetes. ** Glucose Management Indicator (GMI) based on reported mean glucose values.
Calculated using JAEB https://www.jaeb.org/gmi/.

Some users were not included in the analysis because of age not shared.

  • Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August  2020 to dec 2022..

Advanced automation features

MiniMed™ 780G system real-world outcomes

Medtronic-780G-System-Real-World-Evidence-FIG-5

Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August 2020 to Dec 2022..
P value nor significant

In the real-world evidence

Medtronic-780G-System-Real-World-Evidence-FIG-6

Medtronic data on file: MiniMed ™ 780G data was uploaded voluntarily by 61,481 users in EMEA to CareLink™ Personal, from August 2020 to Dec 2022.
Users with recommended optimal settings are the ones using the combination of glucose target setting at 100 mg/dL and Active Insulin Time (AIT) at 2 hours for at least 95% of the time.

FAQ

Q: What is the age range for using the MiniMedTM 780G system?

A: The system is indicated for use by patients aged 7-80 years with Type 1 diabetes.

Q: How many users were included in the analysis for clinical outcomes?

A: The analysis included a total of 61,481 users in the Post-AHCL cohort.

References

Read User Manual Online (PDF format)

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