illumina Hamilton STAR Oncology 500 High Throughput with Hamilton User Guide
- June 15, 2024
- illumina
Table of Contents
illumina Hamilton STAR Oncology 500 High Throughput with Hamilton
Scalable comprehensive genomic profiling
TruSight Oncology 500 High-Throughput is built on the foundation of the TruSight Oncology 500 assay, with flexibility for higher sample throughput and batching options. TruSight Oncology 500:
- Targets key DNA and RNA pan-cancer biomarkers across 523 genes
- Measures large genomic signatures such as microsatellite instability (MSI) and tumour mutational burden (TMB)
- Provides a comprehensive workflow that allows users to go from initial sample to results in 4-5 days
Streamlined library prep
Multiple routine and repetitive pipetting steps performed by lab professionals
are highly amenable to automation solutions that:
- Reduce manual touchpoints and hands-on time
- Decrease variation related to user error
- Increase lab productivity and help achieve high-quality sequencing results reproducibly
Automation partnerships
By partnering with Hamilton, a leading provider of liquid-handling solutions,
Illumina provides qualified automated solutions that are proven to perform at
a level equal to, or better than, manual methods (Figure 1, Figure 2
).
Figure 1: Less hands-on time when automating TruSight Oncology 500 High- Throughput—Illumina Qualified methods on the Hamilton STAR system significantly reduce the hands-on time for library prep.
Figure 2: Consistent performance with automating TruSight Oncology 500 High- Throughput—Illumina Qualified methods on the Hamilton SBS STAR MOA system produce consistent performance and low failure rates.
Scalability with automation
Illumina Qualified methods provide scalability for sample throughput, ranging from 16 to 96 samples in a single run, with the option for parallel processing of DNA and RNA samples (Table 1).
Preconfigured deck layout
The Hamilton SBS STAR MOA features preconfigured workstation layouts designed
in collaboration with Illumina to support the TruSight Oncology 500 assay
(Figure 3).
Learn more
TruSight Oncology 500 High-Throughput Illumina automation solutions
Figure 3: The Hamilton SBS STAR MOA—The Hamilton SBS STAR MOA includes multiple features to support TruSight Oncology High-Throughput, including an on-deck thermal cycler (red box), 96 multiprobe head (yellow box), internal swivel arm plate handler (iSWAP, green box), and a heater-shaker (blue box).
Summary
Illumina has collaborated with Hamilton to provide scalable, automated
solutions for the TruSight Oncology 500 assay that reduce preparation time and
provide consistent performance. Illumina continues to work with automation
partners to deliver a wide range of system options to meet future throughput
and application requirements.
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- M-GL-01729 v1.0
- For Research Use Only. Not for use in diagnostic procedures.
References
- Illumina | Sequencing and array solutions to fuel genomic discoveries
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