thermo scientitic ImmunoCAP gE Testing User Guide

: June 7, 2024
: thermo scientitic

Table of Contents

ImmunoCAP gE Testing
When to order
How to order
How to interpret results
Interpreting elevated results
Read User Manual Online (PDF format)
Download This Manual (PDF format)

scientitic ImmunoCAP gE Testing
User Guide

thermo scientitic ImmunoCAP gE Testing Your quick guide to using
ImmunoCAP Specific IgE testing
Get the full picture of your patients’ suspected
allergy symptoms

ImmunoCAP gE Testing

Ready to get the full picture of your patients’ allergy triggers? This quick guide will show you how to get started.
See how to confidently order, interpret, and apply ImmunoCAP™ Specific IgE blood tests to get the full picture.

When to order

Identify appropriate patients

Look for patients with symptoms and a history of rhinitis, nasal congestion, rhinorrhea, sneezing, coughing, wheezing, chest tightness and/or shortness of breath
These symptoms can indicate the patient is suitable for ImmunoCAP Specific IgE blood testing for respiratory allergens (trees, weeds, grasses, dust mites, molds, cat and dog dander, mouse urine and cockroach)¹

How to order

ImmunoCAP Specific IgE blood testing can be ordered from major or local laboratories
Use a paper requisition or your electronic medical record (EMR) system to place orders
Test codes can be found through your EMR system or lab provider

Need more assistance?
Still not sure how to order? Get in touch and we will connect you with a representative who can help.

How to interpret results

Initial interpretation steps:

Combine ImmunoCAP Specific IgE blood test results with the patient’s history, symptoms, and physical exam findings to inform your understanding and decision-making 3,4

Use the test results applicable only to respiratory allergen result interpretation:

The results indicate the patient’s level of sensitization to specific allergens, measured in kilounits of allergen-specific IgE per liter of blood (kU A /l) 2
Utilize our test interpretation guides to confidently identify and manage allergies

Management considerations

Consider other causes
A negative result for a suspected allergen sensitization still aids in patient care
Negative results help eliminate unnecessary allergen avoidance or ineffective anti-allergic medications, like antihistamines⁴
Categorize results ranked from highest to lowest specific IgE sensitizations
Provide allergen avoidance plan to keep patient below symptom threshold ⁴
– Consider reducing exposure to allergens with the highest specific IgE levels first
– Focus on indoor allergens since these may be easier to control ²
Prescribe appropriate medication if needed, e.g. antihistamines ⁴
If inadequate response or other considerations like allergen immunotherapy (AIT), consider referral to specialist

Interpreting elevated results

Results ≥0.1 kUA/l indicate an allergen sensitization, which, in conjunction with patient history, can be used to help clinically diagnose allergy. ²
Specific IgE normal, total IgE normal

Birch, common silver	<0.10
Cedar, mountain	<0.10
Elm, American	<0.10
Maple/box elder	<0.10
Oak, white	<0.10
Pecan, hickory	<0.10
Nettle	<0.10
Pigweed, common	<0.10
Common ragweed (short)	<0.10
Sheep sorrel	<0.10
Bahia grass	<0.10
Bermuda grass	<0.10
Alternaria alternate	<0.10
Aspergillus fumigatus	<0.10
Cladosporium herbarium	<0.10
Penicillium cryogenic	<0.10
Cat dander	<0.10
Cockroach, German	<0.10
D farinae	<0.10
D pteronyssinus	<0.10
Dog dander	<0.10
Mouse urine	<0.10
Tot a l I gE	10

Consider patient management as if nonallergic

Specific IgE elevated, total IgE normal

Alternaria alternate	<0.10
Aspergillus fumigatus	<0.10
Bermuda grass	<0.10
Birch, common silver	<0.10
Cat dander	4.01
Cladosporium herbarium	<0.10
Cockroach, german	<0.10
Common ragweed (short)	20.13
D farinae	<0.10
D pteronyssinus	<0.10
Dog dander	<0.10
Elm, American	<0.10
Maple/box elder	<0.10
Cedar, mountain	<0.10
Mouse urine proteins	<0.10
Mulberry	<0.10
Oak, white	9.27
Pecan, hickory	<0.10
Penicillium chrysogenum	<0.10
Rough marsh elder	<0.10
Pigweed, common	<0.10
Timothy grass	<0.10
Walnut	<0.10
Tot a l I gE	20

Consider patient management as if allergic ~30% present this way.
This is why it is not recommended to screen with total IgE.
Specific IgE elevated, total IgE elevated

Cedar, mountain	0.12
Cottonwood	0.2
Elm, American	<0.10
Oak, white	<0.10
Olive tree	<0.10
Mug wort	40.34
Pigweed, common	<0.10
Common ragweed (short)	<0.10
Sheep sorrel	<0.10
Thistle, Russian	>100
Bermuda grass	<0.10
Bahia grass	<0.10
Rye grass, perennial	<0.10
Alternaria alternate	<0.10
Aspergillus fumigatus	25.25
Cladosporium herbarium	21.85
Penicillium cryogenic	35.15
Cat dander	<0.10
Cockroach, German	<0.10
D farinae	<0.10
D pteronyssinus	<0.10
Dog dander	11.25
Mouse urine	<0.10
Tot a l I gE	210

Consider patient management as if allergic

Specific IgE normal, total IgE elevated

Alder, grey	<0.10
Birch, common silver	<0.10
Cedar, mountain	<0.10
Cottonwood	<0.10
Elm, american	<0.10
Maple/box elder	<0.10
Oak, white	<0.10
Mugwort	<0.10
Pigweed, common	<0.10
Sheep sorrel	<0.10
Thistle, russian	<0.10
Timothy grass	<0.10
Alternaria alternata	<0.10
Aspergillus fumigatus	<0.10
Cladosporium herbarum	<0.10
Penicillium chrysogenum	<0.10
Cat dander	<0.10
Cockroach, german	<0.10
D farinae	<0.10
D pteronyssinus	<0.10
Dog dander	<0.10
Mouse urine	<0.10
Tot a l I gE	380

Consider additional patient follow up
Reconsider profile, geography, other exposures like furry/feathered animals, medications, or comorbid conditions.

Official product names mentioned within this document: ImmunoCAP Allergen d1, House dust mite, ImmunoCAP Allergen d2, House dust mite, ImmunoCAP Allergen e1, Cat dander, ImmunoCAP Allergen e5, Dog dander, ImmunoCAP Allergen e72, Mouse urine proteins, ImmunoCAP Allergen g17, Bahia grass, ImmunoCAP Allergen g2, Bermuda grass, ImmunoCAP Aergen g5, Rye-grass, ImmunoCAP Allergen g6, Timothy, ImmunoCAP Allergen i6, Cockroach, German, ImmunoCAP Allergen m1, Penicillium chrysogenum, ImmunoCAP Allergen m2, Cladosporium herbarium, ImmunoCAP Allergen m3, Asperges fumigatus, ImmunoCAP Allergen m6, Alternaria alternata, ImmunoCAP Allergen t10, Walnut, ImmunoCAP Allergen t14, Cottonwood, ImmunoCAP Allergen t2, Grey alder, ImmunoCAP Allergen t212, Cedar, ImmunoCAP Allergen t22, Pecan, Hickory, ImmunoCAP Allergen t3, Common silver birch, ImmunoCAP Allergen t7, Oak, ImmunoCAP Allergen t70, Mulberry, ImmunoCAP Allergen t8, Elm, ImmunoCAP Allergen t1, Box-elder, ImmunoCAP Allergen t9, Olive, ImmunoCAP Allergen w1, Common ragweed, ImmunoCAP Allergen w11, Saltwort (prickly), Russian thistle, ImmunoCAP Alergen w14, Common pigweed, ImmunoCAP Allergen w16, Rough marsh elder, ImmunoCAP Allergen w18, Sheep sorrel, ImmunoCAP Allergen w20, Nettle, ImmunoCAP Allergen w6, Mugwort, ImmunoCAP Total IgE
ImmunoCAP ™ Specific IgE blood test results are quantitative. Results above 0.1 kUA /l are indicative of an allergen-specific IgE sensitization.
ImmunoCAP™ Total IgE reference ranges reported in kU/l are dependent on age. Use your lab’s reference range for ImmunoCAP Total IgE located on the results report.²
thermo scientitic ImmunoCAP gE Testing - feager

To sum it up
It’s easier than ever for general practitioners to help allergy patients. Patients want answers and relief. You want the best tools to deliver. That’s why we’ve made it easy to order and interpret ImmunoCAP Specific IgE blood testing.
Because sometimes, you need the full picture to truly optimize your treatment plan.
Get the full picture with ImmunoCAP Specific IgE blood testing.
Order ImmunoCAP Specific IgE blood testing from a major or local laboratory through a paper requisition or your EMR system.

Learn more at thermofisher.com/immunocap/catalog

References

Dykewicz MS et al. (2020) Rhinitis 2020: a practice parameter update. J Allergy Clin Immunol . 146(4):721–767.
ImmunoCAP™ Specific IgE Conjugate 400 Directions for Use. Published 2022-06-02.
DeMolay P, Liu AH, Rodriguez Del Rio P, Pedersen S, Casals TB, Price D (2022) A pragmatic primary practice approach to using specific IgE in allergy testing in asthma diagnosis, management, and referral. J Asthma Allergy. 15:1069–1080.
Papadopoulos NG et al. (2015) Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy. 70 (5):474– 494.

© 2024 Thermop Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher Scientific and its
subsidiaries unless otherwise specified. 378208.AL.ALR.EN.v1.0.24.0