Spravato Esketamine Nasal Spray Device Instruction Manual

: June 6, 2024
: Spravato

Table of Contents

Nasal Spray Device
Step 1 Get ready
Step 2 Prepare device
Step 3 Prepare patient
Step 4 Patient sprays once into each nostril
Step 5 Confirm delivery and rest
Next device
Documents / Resources
- Read User Manual Online (PDF format)
- Download This Manual (PDF format)

Spravato Esketamine Nasal Spray Device

Nasal Spray Device

Each device delivers two sprays containing a total of 28 mg of esketamine.

Step 1 Get ready

Before first device only:
Instruct patient to blow nose before first device only.

Confirm required number of devices.

56 mg = 2 devices

84 mg = 3 devices

Step 2 Prepare device

Healthcare professional:

Check expiration date (`EXP’). If expired, get a new device.
Peel blister and remove device.

Healthcare professional:
Do not prime device. This will result in a loss of medication.
Check that indicator shows 2 green dots. If not, dispose of device and get a new one
Hand device to patient. cp-81317v2

Step 3 Prepare patient

Instruct the patient to:

Hold device as shown with the thumb gently supporting the plunger.
Do not press the plunger.

Instruct the patient to:

Recline head at about
45 degrees during administration to keep medication inside the nose.

Step 4 Patient sprays once into each nostril

Instruct the patient to:

Insert tip straight into the first nostril.
Nose rest should touch the skin between the nostrils.

Instruct the patient to:
Close opposite nostril.
Breathe in through nose whilepushing plunger all the way up until it stops.

Instruct the patient to:
Sniff gently after spraying to keep medication inside nose.

Instruct the patient to:
Switch hands to insert tip into the second nostril.
Repeat Step 4 to deliver second spray.

Step 5 Confirm delivery and rest

Healthcare professional:

Take device from patient.
Check that indicator shows no green dots. If you see a green dot, have patient spray again into the second nostril.
Check indicator again to confirm device is empty.

Instruct the patient to:
Rest in a comfortable position (preferably, semi -reclined) for 5 minutes
after each device.
If liquid drips out, dab nose with a tissue.

Do not blow nose.

Next device

Healthcare professional:

Repeat Steps 2-5 for the next device.

IMPORTANT: Ensure that patient waits 5 minutes after each device to allow medication to absorb.

Disposal
Dispose of used device(s) per facility procedure for a Schedule III drug product and per applicable federal, state, and local regulations.
This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Manufactured for:
Janssen Pharmaceuticals, Inc. Titusville, NJ 08560
Revised: November 2019
© 2019 Janssen Pharmaceutical Companies