PandG In-line, Real time Particle Size Distribution Measurement Instructions
- July 10, 2024
- PandG
Table of Contents
In-line, Real-time Particle Size Distribution Measurement
BACKGROUND
We are developing a fully automated, high-throughput synthesis system. One of the key challenges is integrating an in-line, real-time particle size distribution measurement.
NEED DESCRIPTION
We require a method or instrument that enables us to measure particle size
distribution (PSD) in a manner that can be automated and integrated into a
larger, high-throughput system.
The proposed solution needs to be able to determine PSD of a sample in quasi
real-time over a period of roughly 30 minutes. The PSD of the sample will vary
over this timeframe. Establishing when the target PSD is reached is a critical
step in the process.
The particle size range of interest is between 1-100 um.
Only a minimal amount of sample (up to a few grams) can be consumed by the
measurement over the 30 minute timeframe.
The sample can be particle dense, so auto-dilution of the sample may be
required.
Ideally the cycle time (between sampling and receiving the PSD measurement
result) is kept under a minute and the PSD is measured every 1-2 minutes.
WHAT WE ARE LOOKING FOR
We are seeking a method or instrument that can measure PSD in real-time, and that can be fully automated. Our goal is to find a solution that can be seamlessly integrated into a larger, custombuilt high-throughput system. In addition to PSD instruments, we are also open to consider microfluidics methods or image analysis/AI on microscope slides or other approaches.
WHAT WE ARE NOT LOOKING FOR
- A stand-alone instrument for measuring PSD
- A method still requiring manual intervention steps
- Unproven technology or methods
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