CryoConcepts Vet Dual Delivery Advanced Portable Cryosurgery Instructions
- June 11, 2024
- CryoConcepts
Table of Contents
DUAL DELIVERY ADVANCED
PORTABLE CRYOSURGERY
For Veterinary Use Only
INSTRUCTIONS FOR USE
INTENDED USE
Cry Omega® Vet Dual Delivery is intended for the surgical destruction of
target tissue by applying cryogenic gases at extreme low temperatures. The
list below shows some examples of the typical lesions to be treated.
- Warts
- Eyelid Tumors
- Meibomian Gland Tumors
- Skin Tags
- Distiches
- Papilloma’s
- Adenomas
- Lick Granulomas
- Anal Growths
BACKGROUND
Cryosurgery is routinely used by Veterinary professionals to treat a variety
of lesions (1). Extreme cold works to destroy tissue through lysis of cells
and stasis of vessels. This may occur through the formation of ice and rapid
changes in osmotic pressure. Both work to increase the overall effectiveness
of cryosurgical treatments (1,2).
To successfully destroy topical lesions on companion animals using
cryosurgery, the device must apply extreme cold long enough and at a
sufficiently low temperature to result in a rapid and deep freeze. The
limited capillary network in the dermis and epidermis of companion animals
allows for aggressive treatments without pain or blistering (3,4,5).
Therefore, following treatment, little aftercare is required, and the animal
can be released without any need for sutures or wound care.
Cry Omega® Vet Dual Delivery is a self-contained, multi-use, disposable
cryosurgical device that dispenses out cryogen— a mixture of pentafluoro
ethane and difluoromethane. These gases are immediately at effective
temperatures (-52°C) and require no waiting before use.
Cry Omega® Vet Dual Delivery allows users to choose to apply cryogen using
Applicators (Buds) or specially designed Focused Treatment Tips (Cones). These
two methods of applying cryogen are made easy with Cry Omega® Vet Dual
Delivery because of its patent pending technology and ergonomic design that
allows the cryogen gas to be gently dispensed and applied with one hand.
Cry Omega® Vet Dual Delivery Buds may also be trimmed before use minimizing
any damage to surrounding healthy tissue. The included Cones also come in a
variety of sizes to help Veterinarians treat with precision. Operation is
one-handed, with no splashing, and the operator can observe the gas bubbling
during Cone use allowing control of the timing.
PRINCIPLE OF ACTION
Evaporation of liquified cryogenic gas applied to the skin draws heat from the
tissue. The Cry Omega® Vet Dual Delivery device serves as a reservoir for
cryogen gas delivering it onto the lesion to be treated at -52°C using Cones
or -67°C using Buds. Following treatment, necrosis at the site will occur.
Recovery takes about 10 to 28 days, with new tissue growing inwards from the
surrounding epidermis and the more deeply situated adnexa.
(1,2,3).
The Cry Omega® Vet Dual Delivery unit consists of the following items.
(Note: Trial Kit contents will differ)
One canister of cryogen gas. The canister comes complete with the handle and
trigger onto which a Bud or Cone Adapter may be mounted.
4–Cone Adapters
70–Cones (3mm, 5mm, 7mm, 9mm, 12mm)
1–Cone Selection Guide
20–Buds
1–Neoprene Practice Pad
STORAGE, TRANSPORT, AND CLEANING
The gas supply is pressurized. Protect the unit from direct sunlight and do
not expose to or store at temperatures in excess of 54°C (129°F) or near any
heat source. Cry Omega® Vet Dual Delivery can be operated at ambient room
temperature. Use Cry Omega® Vet Dual Delivery in a well-ventilated room. (See
MSDS for more details). Cry Omega® Vet Dual Delivery may be cleaned with 70%
isopropyl alcohol or a damp cloth and mild detergent.
DISPOSAL
Once the Cry Omega® Vet Dual Delivery device is empty, attach the green release clip by pulling the trigger and inserting the clip. The device may then be discarded according to local regulations or contact your distributor for additional recommendations.
GENERAL PRECAUTIONS
Cryosurgery can produce a painful, burning sensation on the skin.
SUGGESTED INFORMATION FOR THE PET OWNER
Cryosurgery works by destructively freezing target tissue. The uppermost layer
of skin, together with the diseased tissue, will disappear. It will be
replaced by a new healthy layer of skin in 10–28 days. Freezing commences
once cryogen is applied to the skin.
During treatment with Buds or Cones, the affected skin will turn white. From
this point on, the animal may experience a momentary stinging or burning
sensation until the local nerves are numbed. This sensation will fade rapidly
after the Buds or Cones are removed and the treated site is allowed to thaw.
Temporary, visible changes in the intensity of pigmentation may occur
following treatment including slight swelling and reddening of the treatment
site. These are signs of an adequate treatment. No blister should form, and no
wound should appear.
ADDITIONAL WARNINGS
Once the cryogen dispensing has stopped, the white discoloration of the skin
will fade away after a few minutes followed by erythema.
Canine and Feline skin should generally not blister following treatment, and
treatment will generally not create an open wound. If the companion animal
accidentally scratches the site and bleeding is evident, treat with topical
antibiotic and protect the site until it is healed.
Examples of types of lesions for treatment are listed. Treatment of other
types of lesions should only be performed based on the professional’s
experience.
FOLLOW-UP TREATMENT SUGGESTIONS
- Keep the treated area clean.
- Swimming and bathing are permitted.
- Do not allow the animal to pick or scratch the treated area.
- Use a bandage to protect any wound that accidentally forms.
UNDESIRABLE EFFECTS-WARNINGS
- Changes in the intensity of pigmentation or localized hair loss may occur. This will generally take the form of hypopigmentation.
LIST OF LESIONS AND SUGGESTED FREEZE TIMES
The depth of freezing using Cry Omega® Vet Dual Delivery will be dependent
upon the time and technique used. The veterinary literature has many reports
of varying cryogen treatment times. The thickness, location, and hydration of
the target tissue can affect freezing time and therefore outcomes.
In general, the shorter treatment times shown below are for thin skin lesions
and locations while the longest treatment times are for more difficult to
treat lesions.
Veterinarians should be familiar with cryosurgical techniques when using Cry
Omega® Vet Dual Delivery. Buds are for sensitive or hardtop-reach locations
while Cones are generally more aggressive.
| Common Lesions | Freeze Time Ranges |
|---|---|
| Warts | Debride dry thickened layers. Freeze/thaw 3 times Thaw between freezes. |
| Eyelid Tumors | Apply with applicator for 10-20 seconds. |
| Meibomian Gland Tumors | Apply with applicator for 10-20 seconds. |
| Skin Tags | Freeze stalk if possible or freeze/thaw 3 times. Thaw between |
freezes
Distichal| Treat eye-lash margin for 10 seconds with applicator.
Papilloma’s| Freeze/thaw 3 times. Thaw between freezes.
Adenomas| Freeze/thaw 3 times. Thaw between freezes.
Lick Granulomas| Freeze/thaw 3 times. Thaw between freezes.
Anal Growths| Freeze/thaw 3 times. Thaw between freezes.
INSTRUCTIONS FOR ACTIVATION & USE
BUD USE
- Remove the Cry Omega® Vet Dual Delivery device from the packaging.
- Place the BUD snugly into the holder at the top of the device.
- Grip the Cry Omega® Vet Dual Delivery handle and invert the device so that the BUD is directed downward.
- Pull the trigger for 3-5 seconds to saturate the BUD with cryogen. Release the trigger to stop the dispense of cryogen.
- With the BUD remaining attached to the device, place the cold BUD directly onto the lesion for desired seconds.
- Optional: Remove the BUD by gripping the BUD base and pulling to remove it from the dispenser. Use BUD to apply from any angle for the desired number of seconds.
- Freeze/Thaw: If performing repeat freezing, thaw the lesion for 40 seconds before beginning the next freeze. Repeat step 4 above to refill the BUD with cryogen before beginning to refreeze.
- Once the treatment is complete the BUD must be discarded.
CONE USE
-
Remove the Crimea® Vet Dual Delivery device from the packaging.
-
Select a CONE that is approximately 1mm larger than the borders of the lesion being treated.
-
Insert the disposable CONE onto the reusable CONE ADAPTER.
-
Place the CONE and CONE ADAPTER snugly onto the canister.
-
Grip the Crimea® Vet Dual Delivery handle and invert the device so that the CONE is directed downward.
-
Place the assembled dispenser, CONE and CONE ADAPTER over the lesion. Pull the trigger for 3–5 seconds until bubbling of the gas can be seen within the lower part of the CONE. Release the trigger to stop the dispense of cryogen.
NOTE: Use enclosed neoprene pad for practice.
-
Hold the CONE and CONE ADAPTER over the lesion until the bubbling stops.
-
Freeze/Thaw: If performing repeat freezing, thaw the lesion for 40 seconds before beginning the next freeze starting with Step 6 above.
-
Once the treatment is complete the CONE must be discarded.
ADDITIONAL PROCEDURE SUGGESTIONS
-
Buds may be most appropriate when treating hard to reach or thin-skin surfaces.
-
To help focus the bud onto a lesion and minimize damage to surrounding healthy tissue, trim the tip as shown on right.
-
Avoid touching the lesion during the thaw phase following treatment
-
Use Freeze-thaw cycles when treating deep or difficult lesions.
-
Buds are not interchangeable between animals and should be discarded after use with the primary animal.
-
Buds may be used to treat multiple lesions on a single animal.
They may also be recharged with additional cryogen between lesions. -
Buds may be used immediately after dispensing cryogen. They are immediately at effective temperature.
-
Resolution rates will improve with freeze-thaw cycles.
-
Cryosurgical research suggests that a narrow strip of healthy tissue should be frozen along with the target tissue for maximum effectiveness (3).
REFERENCES
- Seam HB, Mechanisms of Cold-Induced Cellular Death. Veterinary Clinical of North America, Small Animal Practice, 10:4, 755-762 (1980)
- Lane JG, Practical Cryosurgery-an introduction for small animal Clinicians. J. Small Anim. Pract. 15, 715-725 (1974)
- Gage AA, Bakst J, Mechanisms of Tissue Injury in Cryosurgery. Cryobiology, 37, 171-186 (1998)
- Gage AA, What Temperature is Lethal for Cells? J Dermatology Surge Ondol, 5-6 (1979)
- Pavlovic MM, Anatomy and circulation of the canine skin. Microsurgery, 12, 103-112 (1991)
TABLE OF SYMBOLS
| **** | INSTRUCTIONS FOR USE |
|---|---|
| CAUTION/ATTENTION | |
| WARNING | |
| **** | MANUFACTURER |
Manufacturer:
Cory Concepts LP
205 Webster Street
Bethlehem, PA 18015, USA
www.cryoconcepts.com
205 Webster Street • Bethlehem, PA 18015 • USA
1-855-355-CRYO (2796) •
support@cryoconcepts.com
www.cryoconcepts.com
Cry Omega® Vet Dual Delivery Cryosurgical System
is a registered trademark of Cry Concepts, LP.
Patents Pending
Documents / Resources
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CryoConcepts Vet Dual Delivery Advanced Portable
Cryosurgery
[pdf] Instructions
Vet Dual Delivery Advanced Portable Cryosurgery, Vet Dual, Delivery Advanced
Portable Cryosurgery, Advanced Portable Cryosurgery, Portable Cryosurgery,
Cryosurgery
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