Honeywell HFO-1234ze RESEARCH Dose Inhaler Instructions

: June 1, 2024
: Honeywell

Table of Contents

PROPELLANT ONLY
SALBUTAMOL
FLUTICASONE
BECLOMETHASONE
IPRATROPIUM BROMIDE
BUDESONIDE
FORMOTEROL
GLYCOPYRROLATE
ROFLUMILAST
References
Read User Manual Online (PDF format)
Download This Manual (PDF format)

HFO-1234ze
RESEARCH Honeywell HFO 1234ze RESEARCH Dose
Inhaler

PROPELLANT ONLY

Droplet Size, Charge, and Velocity – Fundamental properties of propellant aerosols can guide transition to low global warming potential pMDIs size, velocity and surface charge; Rosi, 2021
Propellant Overview – A Journey to Net Zero Using Solstice Air; Hulse, 2022
Leachables – Investigation of Leachables from pMDIs Containing Propellants HFA134a, HFA152a, and HFO1234ze; Le Corre, 2022
Charge, droplet diameter, velocity – The Formulators Guide to Transitioning to Low GWP pMDIs; Shur, 2022
Propellant Overview – HFO-1234ze(E) Propelling Towards Carbon Neutrality; Boldt, 2022
Saturated vapor pressure w/EtOH – Saturated Vapor Pressure of HFA-152a Ethanol and HFO-1234ze Ethanol Mixtures; Vutlapalli, 2022
Liquid Density w/EtOH – Determining measured experimental values of density to aid formulation development of new environmentally friendly propellant mixtures with Ethanol; Harrison, 2022
Spray Plume Characteristics – In-Vitro Evaluation of pMDI Spray Development of HFA134a, HFA152a, and HFO1234zeE; Rao, 2022
Saturated Vapor Pressure w/EtOH – Measurement of the Saturated Vapor Pressure of Low-GWP Propellants in Conjuction with Ethanol; Thorne, 2022
Plume Dynamics – In-Silico Prediction of pMDI Performance with Low-GWP Propellants HFA152a and HFO1234ze; Duke, 2022
Flammability – HFO1234ze Flammability Characterization for MDI Manufacturing; Close, 2023
Filling, Leakage, Shot Weight – Filling and Dose Performance of pMDIs with New Low GWP Propellants; Deraime, 2023
Extractables and Leachables – Leachables Assessment from a New Generation of pMDI Using Low GWP Propellants; Faucard, 2023
Droplet Size, Water Content – Droplet Characteristics of Low GWP Propellants at Different Ambient Humidities; Wang, 2023
Spray Pattern, Plume Geometry – Spray Pattern and Plume Geometry Measurements of Current and Low GWP Propellants HFA152a and HFO1234ze(E) pMDIs With and Without Ethanol; Myatt, 2023
Non-Clinical Toxicology – The Nonclinical Assessment of HFO1234ze a Near Zero GWP Propellant for Use in MDI Products; Griffen, 2023
Valve and Can Deposition – Canister Valve and Actuator Deposition in MDIs Formulated with Low-GWP Propellants; Duke, 2023
TFA Creation – pMDIs Using Next-Generation Proplleant HFO1234ze Deposit Negligible Amounts of TFA in the Environment; Tewari, 2023

SALBUTAMOL

Sedimentation Rate – The Formulators Guide to Transitioning to Low GWP pMDIs; Shur, 2022
Suspended Particle Size Distribution – Direct PSD Measurement of an Active Ingredient Suspended in pMDIs and Parameters Which Influence Migration Rate; Rey Blanes, 2022
Firing angle, flow rate, throat size on APSD – An Evaluation of Solution and Suspension pMDIs Containing HFA152a and HFO1234ze Using Clinically Relevant Test Methods; Brittain, 2023
Spray Characteristics, Droplet Size, APSD – Optimizing Spray Formation in Solution and Suspension Low GWP MDIs; Duke, 2023
Suspension Stability – Physical Stability of Salbutamol Sulfate Suspensions in HFA-134a and HFO-1234ze(E); Boldt, 2023
DDU, APSD, Spray Pattern, Plume Geometry – Feasibility Development of Salbutamol Sulphate Pressurized Metered Dose Inhalers using a Low Global Warming Potential Propellant 1,3,3,3-Tetrafluoropropene (HFO1234ze); Mao, 2023
DDU, APSD, Stability Data – Understanding fundamental formulation properties to demonstrate the feasibility of reformulating a salbutamol pMDI containing the low GWP propellant HFO1234ze(E); Slowey, 2023

FLUTICASONE

APSD, Particle Size – Device and formulation parameters influencing pressurised MeteredDose Inhaler (pMDI) aerosols using HFO1234ze propellant; Thorne, 2023

BECLOMETHASONE

Solubility – The Formulators Guide to Transitioning to Low GWP pMDIs; Shur, 2022
Droplet Size, APSD – Solution Based pMDI Formulations Using HFA134a, HFA152a, and HFO1234ze Propellants Analysis of Size, Aerosolization Performance and Particle Morphology; Marasini, 2022
Firing angle, flow rate, throat size on APSD – An Evaluation of Solution and Suspension pMDIs Containing HFA152a and HFO1234ze Using Clinically Relevant Test Methods; Brittain, 2023
Spray Characteristics, Droplet Size, APSD – Optimizing Spray Formation in Solution and Suspension Low GWP MDIs; Duke, 2023
Particle Dissolution Rates, Morphology – Do In-vitro dissolution rates differ between beclomethasone dipropionate particles generated from solution-based pMDIs formulated with HFA134a, HFA152a and HFO1234ze(E) propellants; Ong, 2023

IPRATROPIUM BROMIDE

Sedimentation Rate – The Formulators Guide to Transitioning to Low GWP pMDIs; Shur, 2022

BUDESONIDE

APSD w/ radiolabeling – Radiolabeling of Low GWP pMDI Formulations for Scintigraphy; Warren, 2022
APSD, DDU, Plume Geometry – Comparative Aerosol Performance of an HFA134a Based Fixed-Dose Triple Combination pMDI to One Made with a Near-Zero Carbon Footprint Propellant; Lachacz, 2023
APSD – Quadruple Combination in a pMDI with Reduced Environmental Impact for the Treatment of COPD; Lechuga, 2023

FORMOTEROL

APSD w/ radiolabeling – Radiolabeling of Low GWP pMDI Formulations for Scintigraphy; Warren, 2022
APSD, DDU, Plume Geometry – Comparative Aerosol Performance of an HFA134a Based Fixed-Dose Triple Combination pMDI to One Made with a Near-Zero Carbon Footprint Propellant; Lachacz, 2023
APSD – Quadruple Combination in a pMDI with Reduced Environmental Impact for the Treatment of COPD; Lechuga, 2023

GLYCOPYRROLATE

APSD w/ radiolabeling – Radiolabeling of Low GWP pMDI Formulations for Scintigraphy; Warren, 2022
APSD, DDU, Plume Geometry – Comparative Aerosol Performance of an HFA134a Based Fixed-Dose Triple Combination pMDI to One Made with a Near-Zero Carbon Footprint Propellant; Lachacz, 2023
APSD – Quadruple Combination in a pMDI with Reduced Environmental Impact for the Treatment of COPD; Lechuga, 2023